Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Burke, W. J. Articles by McComb, R. D. Search for Related Content PubMed Citation Articles by Burke, W. J. Articles by McComb, R. D. Dementias (General) Other Neuroleptics

Neuroleptic Sensitivity to Clozapine in Dementia With Lewy Bodies

Received January 28, 1997; revised May 23, 1997; accepted May 30, 1997. From the Departments of Psychiatry, Neurology, and Pathology/Microbiology, University of Nebraska Medical Center, Omaha, Nebraska. Address correspondence to Dr. Burke, 600 South 42nd Street, Omaha, NE 68198-5575; e-mail: wjburke{at}mail.unmc.edu

Dementia with Lewy bodies (DLB) may be one of the most common causes of dementia. It should be of particular interest to psychiatrists because hallucinations are common presenting symptoms and because patients with DLB may be particularly sensitive to neuroleptics with respect to developing extrapyramidal symptoms. The authors describe 2 patients with DLB who were intolerant of clozapine, showing not extrapyramidal side effects, but an increase in confusion and behavioral symptoms.

Key Words: Dementia With Lewy Bodies • Clozapine • Neuroleptic Medications

This article has been cited by other articles:

				I. G. McKeith, D. W. Dickson, J. Lowe, M. Emre, J. T. O'Brien, H. Feldman, J. Cummings, J. E. Duda, C. Lippa, E. K. Perry, et al. Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium Neurology, December 27, 2005; 65(12): 1863 - 1872. [Abstract] [Full Text] [PDF]

				M. Simard and R. van Reekum The Acetylcholinesterase Inhibitors for Treatment of Cognitive and Behavioral Symptoms in Dementia With Lewy Bodies J Neuropsychiatry Clin Neurosci, November 1, 2004; 16(4): 409 - 425. [Abstract] [Full Text] [PDF]

				M D Greicius, M D Geschwind, and B L Miller Presenile dementia syndromes: an update on taxonomy and diagnosis J. Neurol. Neurosurg. Psychiatry, June 1, 2002; 72(6): 691 - 700. [Abstract] [Full Text] [PDF]

				M. F. Mendez and A. Lipton Emergent Neuroleptic Hypersensitivity as a Herald of Presenile Dementia J Neuropsychiatry Clin Neurosci, August 1, 2001; 13(3): 347 - 356. [Abstract] [Full Text] [PDF]

				M. Simard, R. van Reekum, and T. Cohen A Review of the Cognitive and Behavioral Symptoms in Dementia With Lewy Bodies J Neuropsychiatry Clin Neurosci, November 1, 2000; 12(4): 425 - 450. [Abstract] [Full Text]

				I. Litvan and A. McKee Clinicopathologic Case Report J Neuropsychiatry Clin Neurosci, February 1, 1999; 11(1): 107 - 112. [Full Text]

Get information about faster international access.

Privacy Policy

Copyright © 1998 American Neuropsychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us