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A Review of Lewy Body Disease, an Emerging Concept of Cortical Dementia

Received January 7, 1997; revised May 16, 1997; accepted May 30, 1997. From the Departments of Neurology, Pathology and Laboratory Medicine, Psychiatry, and Environmental Medicine, University of Rochester Alzheimer's Disease Center, University of Rochester Medical Center, Rochester, New York. Address correspondence to Dr. Papka, Department of Neurology, Box 673, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642.

Dementia associated with cortical Lewy bodies on neuropathologic examination may comprise the second largest category of age-related cognitive impairment, after Alzheimer's disease. Despite its prevalence, a consensus has not yet been reached regarding the terminology, neuropathologic criteria, or clinical symptomatology of this postulated nosologic entity. Lewy body disease (LBD) is beginning to be diagnosed clinically in neuropsychiatric clinics, but universally accepted diagnostic criteria for LBD remain to be validated. In this article the authors review the literature on LBD, including both neuropathologic and clinical findings.

Key Words: Lewy Body Disease • Alzheimer's Disease • Parkinson's Disease

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