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Prevalence and Correlates of Aggressive Behavior in Alzheimer's Disease

Received September 4, 1997; revised December 23, 1997; accepted March 12, 1998. From the Departments of Neuropsychiatry and Clinical Neurology, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina. Address correspondence to Dr. Chemerinski, FLENI, Montañeses 2325, 1428 Buenos Aires, Argentina; e-mail: eran{at}fleni.org.ar

The authors assessed a consecutive series of 196 patients with probable Alzheimer's disease (AD) for the presence of aggressive behavior, using a standardized neurological, neuropsychiatric, and neuropsychological battery that included both the Overt Aggression Scale and the Irritability Scale. Twelve percent of patients showed aggressive episodes (5% with verbal aggression, 7% with physical aggression) during the 4 weeks preceding the psychiatric evaluation. Physical aggression was significantly associated with more frequent delusions and more severe irritability.

Key Words: Alzheimer's Disease • Irritability • Aggression

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