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Alteration of Regional Cerebral Glucose Utilization With Delusions in Alzheimer's Disease

Received June 24, 1997; revised September 3, 1997; accepted October 27, 1997. From the Divisions of Clinical Neuroscience and Neuroimaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders, Hyogo, Japan. Address correspondence to Dr. Hirono, Division of Clinical Neuroscience, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho-ko, Himeji, Hyogo, 670, Japan.

The authors examined 65 patients with Alzheimer's disease for delusions and explored the relationship of delusions with regional cerebral glucose metabolism determined by [¹⁸F]fluorodeoxyglucose PET. In patients with delusions (n=26), normalized glucose metabolism was significantly increased in the left inferior temporal gyrus and significantly decreased in the left medial occipital region as compared with those without delusions (n=39). The two groups were similar in age, sex, and dementia severity. These results suggest that delusions in Alzheimer's disease are attributable to a dysfunction in specific brain areas rather than a simple reaction to intellectual deficits.

Key Words: Alzheimer's Disease • Delusions • Cerebral Blood Flow and Metabolism

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