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J Neuropsychiatry Clin Neurosci 10:456-458, November 1998
© 1998 American Psychiatric Press, Inc.


Clinical and Research Report

Psychotic Symptoms in Dementia Associated With Motor Neuron Disease

A Pathophysiological Hypothesis

Ricardo Nitrini, M.D. and Sérgio Rosemberg, M.D.

Received February 5, 1997; revised March 17, 1997; accepted August 14, 1997. From the Departments of Neurology and Pathology, Faculty of Medicine, University of São Paulo, Brazil. Address correspondence to Dr. Nitrini, Rua Bartolomeu Feio, 560, 04580-001 São Paulo, Brazil; e-mail: rnitrini{at}usp.br

Three patients with neuropathologically confirmed frontotemporal dementia, motor neuron disease type, manifested hallucinations. In this dementia, the superficial layers of the frontal and temporal cortices are predominantly affected. Hallucinations may emerge as release phenomena secondary to selective laminar cortical involvement.

Key Words: Dementia • Motor Neuron Disease • Psychotic Symptoms




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D. Velakoulis, M. Walterfang, R. Mocellin, C. Pantelis, and C. McLean
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