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Correlates of Executive Function in Multiple Sclerosis:

The Use of Magnetic Resonance Spectroscopy as an Index of Focal Pathology

Received September 22, 1997; revised January 5, 1998; accepted January 7, 1998. From the Institute of Neurology, London, UK. Address correspondence to Dr. Foong, Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom.

Proton magnetic resonance spectroscopy (MRS) was performed in a group of patients with multiple sclerosis (MS) and matched control subjects to examine the relationship between frontal lobe pathology and performance on tests of executive function. The N-acetyl aspartate/creatine ratio (NAA/Cr) was significantly reduced in frontal lesions and/or normal-appearing white matter in the patient group compared with the control group, but choline/creatine ratios did not differ. Although MRS abnormalities and executive deficits were not correlated for MS patients as a group, a few patients with more severe abnormalities of NAA/Cr ratio performed worse than other patients on the spatial working memory test, suggesting that subtle frontal neuropathological abnormalities detected by MRS may contribute to executive deficits. Further investigation is warranted to determine the value of MRS as an index of the pathophysiological processes leading to cognitive deficit.

Key Words: Multiple Sclerosis • Magnetic Resonance Spectroscopy • Executive Function

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