Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Diaz-Olavarrieta, C. Articles by Garcia de al Cadena, C. Search for Related Content PubMed Citation Articles by Diaz-Olavarrieta, C. Articles by Garcia de al Cadena, C. Anxiety Disorders (General) Other Neuropsychiatric Disorders

Neuropsychiatric Manifestations of Multiple Sclerosis

Received October 23, 1997; revised February 25, 1998; accepted April 7, 1998. From the Laboratory of Experimental Psychology, Research Division, National Institute of Neurology and Neurosurgery of Mexico, Mexico City, Mexico, and the Departments of Neurology and Psychiatry/Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California. Address correspondence to Dr. Cummings, Reed Neurological Research Center, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095–1769.

The range of neuropsychiatric symptoms in multiple sclerosis (MS) has not been prospectively assessed. The authors, working at a tertiary medical center in Mexico City, used the Neuropsychiatric Inventory (NPI) to evaluate neuropsychiatric symptoms prospectively in 44 MS patients who were stable between relapses and 25 control subjects of similar age, education, and cognitive function. Neuropsychiatric symptoms were present in 95% of patients and 16% of control subjects. Changes present were depressive symptoms (79%), agitation (40%), anxiety (37%), irritability (35%), apathy (20%), euphoria (13%), disinhibition (13%), hallucinations (10%), aberrant motor behavior (9%), and delusions (7%). The only relationships with MRI were between euphoria and hallucinations and moderately severe MRI abnormalities. The authors conclude that diverse types of neuropsychiatric symptoms are common in MS; symptoms are present between exacerbations; and there are variable correlations with MRI abnormalities.

Key Words: Multiple Sclerosis • Anxiety • Agitation

This article has been cited by other articles:

				J. M. Bruce, A. S. Bruce, L. Hancock, and S. Lynch Self-reported Memory Problems in Multiple Sclerosis: Influence of Psychiatric Status and Normative Dissociative Experiences Arch Clin Neuropsychol, February 1, 2010; 25(1): 39 - 48. [Abstract] [Full Text] [PDF]

				J. H Choi and U. W Preuss Relapsing-remitting type multiple sclerosis with olfactory hallucinosis and secondary delusions BMJ Case Reports, May 25, 2009; 2009(may25_1): bcr0220091554 - bcr0220091554. [Abstract] [Full Text]

				I. S. Haussleiter, M. Brune, and G. Juckel Review: Psychopathology in multiple sclerosis: diagnosis, prevalence and treatment Therapeutic Advances in Neurological Disorders, January 1, 2009; 2(1): 13 - 29. [Abstract] [PDF]

				M Korostil and A Feinstein Anxiety disorders and their clinical correlates in multiple sclerosis patients Multiple Sclerosis, January 1, 2007; 13(1): 67 - 72. [Abstract] [PDF]

				F. Ortiz, L. J. Fitten, J. L. Cummings, S. Hwang, and M. Fonseca Neuropsychiatric and behavioral symptoms in a community sample of Hispanics with Alzheimer's disease. American Journal of Alzheimer's Disease and Other Dementias, August 1, 2006; 21(4): 263 - 273. [Abstract] [PDF]

				M. P. Sanfilipo, R. H.B. Benedict, B. Weinstock-Guttman, and R. Bakshi Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis Neurology, March 14, 2006; 66(5): 685 - 692. [Abstract] [Full Text] [PDF]

				R. van Reekum, D. T. Stuss, and L. Ostrander Apathy: Why Care? J Neuropsychiatry Clin Neurosci, February 1, 2005; 17(1): 7 - 19. [Abstract] [Full Text] [PDF]

				I. Fishman, R. H. B. Benedict, R. Bakshi, R. Priore, and B. Weinstock-Guttman Construct Validity and Frequency of Euphoria Sclerotica in Multiple Sclerosis J Neuropsychiatry Clin Neurosci, August 1, 2004; 16(3): 350 - 356. [Abstract] [Full Text] [PDF]

				A. A. Asghar-Ali, K. H. Taber, R. A. Hurley, and L. A. Hayman Pure Neuropsychiatric Presentation of Multiple Sclerosis Am J Psychiatry, February 1, 2004; 161(2): 226 - 231. [Full Text] [PDF]

				R H. Benedict, I Fishman, M M McClellan, R Bakshi, and B Weinstock-Guttman Validity of the Beck Depression Inventory-Fast Screen in multiple sclerosis Multiple Sclerosis, August 1, 2003; 9(4): 393 - 396. [Abstract] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 1999 American Neuropsychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us