J Neuropsychiatry Clin Neurosci 11:66-70, February 1999
© 1999 American Psychiatric Press, Inc.
Lack of Effect of Apolipoprotein E E4 Allele on Neuropsychiatric Manifestations in Alzheimer's Disease
Nobutsugu Hirono, M.D.,
Etsuro Mori, M.D.,
Minoru Yasuda, M.D.,
Toru Imamura, M.D.,
Tatsuo Shimomura, M.D.,
Mamoru Hashimoto, M.D.,
Satoshi Tanimukai, M.D.,
Hiroaki Kazui, M.D. and
Hikari Yamashita, M.A.
Received December 8, 1997; revised February 18, 1998; accepted March 4, 1998. From the Divisions of Clinical Neurosciences and Basic Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan. Address correspondence to Dr. Hirono, Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho-ko, Himeji, 670, Japan; e-mail: hirono{at}hiabcd.go.jp
The association between the apolipoprotein E epsilon 4 (APOE E4) allele and a wide spectrum of behavioral symptoms of Alzheimer's disease (AD) was investigated. Neither the severity nor the presence of any behavioral changes was associated with the number of APOE E4 alleles, even after controlling for the effects of age at onset, sex, education level, duration of illness, and severity of dementia. The findings do not support the hypothesis that neuropsychiatric manifestations of AD are different in patients with the APOE E4 allele.
Key Words: Alzheimer's Disease • Apolipoprotein E
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