J Neuropsychiatry Clin Neurosci 11:71-78, February 1999
© 1999 American Psychiatric Press, Inc.
Reduced Volume of Limbic System–Affiliated Basal Ganglia in Mood Disorders:
Preliminary Data From a Postmortem Study
Bruno Baumann, M.D.,
Peter Danos, M.D.,
Dieter Krell,
Silvia Diekmann, M.D.,
Andreas Leschinger, M.D.,
Renate Stauch,
Cornelius Wurthmann, M.D.,
Hans-Gert Bernstein, Ph.D. and
Bernhard Bogerts, M.D.
Received December 4, 1997; revised March 31, 1998; accepted April 7, 1998. From the Department of Psychiatry, University of Magdeburg, Magdeburg, Germany. Address correspondence to Dr. Baumann, Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D-39120 Magdeburg, Germany.
Volumes of basal ganglia in postmortem brains of 8 patients with mood disorders and 8 control subjects without neuropsychiatric disorder were determined. Morphometry of serial whole-brain sections under the control of postmortem artifacts revealed reduced volumes of the left nucleus accumbens (–32%, P=0.01), the right and left external pallidum (–20%, P=0.04), and the right putamen (–15%, P=0.04) in the patient group compared with the control group. These results suggest that, in particular, the limbic loop of the basal ganglia involving the nucleus accumbens and the pallidum is affected in mood disorders.
Key Words: Limbic System • Basal Ganglia • Mood Disorders
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