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Patterns of Relative Cerebral Blood Flow in Minor Cognitive Motor Disorder in Human Immunodeficiency Virus Infection

Received December 17, 1997; revised February 26, 1998; accepted August 27, 1998. From the Neuropsychology Research Program and Center for Functional Brain Imaging, Departments of Radiology, Psychiatry, and Neurology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and Leopold Müller Functional Imaging Laboratory, Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK. Address correspondence to Dr. Becker, Suite 502, Iroquois Building, 3600 Forbes Avenue, Pittsburgh, PA 15213.

Individuals infected with HIV are at risk to develop cognitive impairment during the course of their disease. Although many patients develop an HIV-associated dementia, others may develop the less severe minor cognitive motor disorder (MCMD). In this study, relative cerebral blood flow was measured with PET imaging in HIV+ MCMD patients, HIV+ control subjects, and HIV– control subjects; analyses were performed by using statistical parametric mapping. Comparing a short-term memory task versus a rest state yielded activation in superior temporal cortex, postcentral gyrus, and cerebellum in all three subject groups. Comparing long- and short-term memory tasks yielded activation throughout the frontal cortex, including BA46. Activation in this area was reduced in the HIV+ control subjects and further reduced in the MCMD+ patients. Thus, brain activation associated with lower-level, automatic processing appears normal in HIV+ MCMD+ subjects, but activation associated with effortful retrieval and organizational processes is abnormal.

Key Words: Human Immunodeficiency Virus, Type 1 • Neuropsychiatric Disorders • Cerebral Blood Flow and Metabolism

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				R. W. Price, L. G. Epstein, J. T. Becker, P. Cinque, M. Gisslen, L. Pulliam, and J. C. McArthur Biomarkers of HIV-1 CNS infection and injury Neurology, October 30, 2007; 69(18): 1781 - 1788. [Abstract] [Full Text] [PDF]

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