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CNS Sjögren's Syndrome

An Underrecognized and Underappreciated Neuropsychiatric Disorder

Received July 24, 1997; revised October 29, 1997; accepted October 29, 1998. From the Department of Psychiatry, University of California, Davis, Sacramento, California. Address correspondence to Dr. Cox, University of California, Davis, Department of Psychiatry, 2230 Stockton Blvd., Sacramento, CA 95817.

Sjögren's syndrome is a common medical condition that may produce psychiatric symptoms. Untreated deficits can become permanent, sometimes resulting in death. The hypothesized mechanism involves CNS vasculitis. Psychoactive medications treat psychiatric symptoms but leave the underlying medical process unaffected. Laboratory tests to diagnose Sjögren's syndrome and specific treatments for this condition are improving.

Key Words: Sjögren's Syndrome • Vascular Disease • Mood Disorders • Autoimmune Disorders

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