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Use of Donepezil for Vascular Dementia

Preliminary Clinical Experience

Received August 7, 1998; accepted December 14, 1998. From the Departments of Neurology and Psychiatry, UCLA School of Medicine, Los Angeles, California. Address correspondence to Dr. Mendez, Neurobehavior Unit (116AF), West Los Angeles VAMC, 11301 Wilshire Boulevard, Los Angeles, CA 90073.

ABSTRACT

The investigators evaluated donepezil, an acetylcholinesterase inhibitor, for vascular dementia. Eight outpatients with subcortical lesions and mild to moderate cognitive impairment received donepezil for 6 months. During this period, cognitive measures remained stable and caregivers reported improved patient activity, engagement, and self-care.

Key Words: Geriatric Neuropsychiatry • Dementia, Vascular • Donepezil

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