J Neuropsychiatry Clin Neurosci 11:361-369, August 1999
© 1999 American Psychiatric Press, Inc.
Dose-Related Neurobehavioral Effects of Chronic Cocaine Use
Karen I. Bolla, Ph.D.,
Richard Rothman, M.D. Ph.D. and
Jean Lud Cadet, M.D.
Received February 2, 1998; revised March 25, 1998; accepted June 10, 1998. From the Department of Neurology, Johns Hopkins University School of Medicine, Hopkins Bayview Research Campus, and Molecular Neuropsychiatry and Clinical Psychopharmacology Sections, National Institutes of Health/National Institute on Drug Abuse-IRP, Baltimore, Maryland. Address correspondence to Dr. Bolla, Johns Hopkins Bayview Medical Center, Department of Neurology, 4940 Eastern Ave., Baltimore, MD 21224 or to Dr. Cadet, Molecular Neuropsychiatry Section, NIDA-IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224.
Although cocaine use is a significant public health problem, there is a paucity of scientific data on long-term neurobehavioral effects. This study examined the dose-related association between chronic cocaine use and neurobehavioral performance. A battery of neuropsychological tests was administered to 30 abstinent chronic cocaine abusers and 21 non–drug-using control subjects matched for age, education, and intelligence. After controlling for age, education, and intellectual ability, greater use of cocaine (grams per week) was associated with larger decrements on tests measuring executive functioning, visuoperception, psychomotor speed, and manual dexterity. These results suggest that chronic cocaine use is associated with persistent decrements in cognitive function that are most pronounced in heavy users. Knowledge of specific cognitive processing deficits in chronic cocaine users would be useful for designing individually tailored drug treatment programs.
Key Words: Substance Use • Neurobehavioral Effects • Cocaine
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