J Neuropsychiatry Clin Neurosci 11:470-474, November 1999
© 1999 American Psychiatric Press, Inc.
An MRI Study of the Corpus Callosum and Cerebellum in Mentally Retarded Autistic Individuals
Facundo Manes, M.D.,
Joseph Piven, M.D.,
Daniela Vrancic, Ph.D.,
Valeria Nanclares, Ph.D.,
Christian Plebst, M.D. and
Sergio E. Starkstein, M.D., Ph.D.
Received November 17, 1998; revised January 25, 1999; accepted April 20, 1999. From the Division of Child Psychiatry, Department of Neuropsychiatry, Raúl Carrea Institute of Neurological Research–FLENI, Buenos Aires, Argentina; and the Department of Psychiatry, University of Iowa, Iowa City, Iowa. Address correspondence to Dr. Starkstein, Montañeses 2325, 1428 Buenos Aires, Argentina. e-mail: ses{at}fleni.org.ar
The areas of seven subregions of the corpus callosum and three subregions of the cerebellum were examined on midsagittal magnetic resonance imaging scans of 27 low-IQ autistic individuals and 17 nonautistic individuals of comparable mental age. Autistic individuals had a significantly smaller corpus callosum (most marked in the body). No significant between-group differences were found in cerebellum areas. Results demonstrate that abnormalities of the corpus callosum reported in high-functioning autistic individuals are also present in autistic individuals with mental retardation and extend previous reports showing no evidence for a selective hypoplasia of cerebellar lobules VI–VII.
Key Words: Autism • Corpus Callosum • Cerebellum • MRI
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