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An MRI Study of the Corpus Callosum and Cerebellum in Mentally Retarded Autistic Individuals

Received November 17, 1998; revised January 25, 1999; accepted April 20, 1999. From the Division of Child Psychiatry, Department of Neuropsychiatry, Raúl Carrea Institute of Neurological Research–FLENI, Buenos Aires, Argentina; and the Department of Psychiatry, University of Iowa, Iowa City, Iowa. Address correspondence to Dr. Starkstein, Montañeses 2325, 1428 Buenos Aires, Argentina. e-mail: ses{at}fleni.org.ar

The areas of seven subregions of the corpus callosum and three subregions of the cerebellum were examined on midsagittal magnetic resonance imaging scans of 27 low-IQ autistic individuals and 17 nonautistic individuals of comparable mental age. Autistic individuals had a significantly smaller corpus callosum (most marked in the body). No significant between-group differences were found in cerebellum areas. Results demonstrate that abnormalities of the corpus callosum reported in high-functioning autistic individuals are also present in autistic individuals with mental retardation and extend previous reports showing no evidence for a selective hypoplasia of cerebellar lobules VI–VII.

Key Words: Autism • Corpus Callosum • Cerebellum • MRI

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