J Neuropsychiatry Clin Neurosci 11:490-497, November 1999
© 1999 American Psychiatric Press, Inc.
Remote Memory in Alzheimer's Disease
María Flavia Dorrego, Ph.D.,
Liliana Sabe, Ph.D.,
Agustina García Cuerva, Ph.D.,
Gabriela Kuzis, Ph.D.,
Cecilia Tiberti, Ph.D.,
François Boller, M.D. and
Sergio E. Starkstein, M.D., Ph.D.
Received September 16, 1998; revised December 14, 1998; accepted April 21, 1999. From the Department of Neuropsychiatry, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina; and Unite 324 INSERM, Paris, France. Address correspondence to Dr. Dorrego, Raúl Carrea Institute of Neurological Research, Montañeses 2325, 1428 Buenos Aires, Argentina; e-mail: ses{at}fleni.org.ar
The authors examined the severity and type of deficits in remote memory in patients with probable Alzheimer's disease (AD). In the first study, 40 AD patients showed significantly more severe deficits on both the free-recall and the recognition sections of the Remote Memory Scale (which measures memory for famous people and well-known events) compared with normal control subjects. In the second study, 25 AD patients showed significantly more deficits on the free-recall section of the Autobiographical Memory Scale compared with normal control subjects. Remote memory deficits in AD may be related to both retrieval deficits and damage to memory traces.
Key Words: Alzheimer's Disease • Memory • Neuropsychology
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