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* Dementias (General)
J Neuropsychiatry Clin Neurosci 11:498-503, November 1999
© 1999 American Psychiatric Press, Inc.

Distinctive Neurobehavioral Features Among Neurodegenerative Dementias

Nobutsugu Hirono, M.D., Etsuro Mori, M.D., Satoshi Tanimukai, M.D., Hiroaki Kazui, M.D., Mamoru Hashimoto, M.D., Tokiji Hanihara, M.D. and Toru Imamura, M.D.

Received December 9, 1998; revised April 8, 1999; accepted April 21, 1999. From the Divisions of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan. Address correspondence to Dr. Nobutsugu Hirono, Division of Clinical Neuroscience, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho-ko, Himeji, 670-0981, Japan; e-mail: hirono{at}hiabcd.go.jp

The distinctive neuropsychiatric features of Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD) were investigated by using the Neuropsychiatric Inventory. The patients with FTD had significantly more euphoria, aberrant motor activity, and disinhibition and significantly fewer delusions compared with the patients with AD or DLB. The patients with DLB had significantly more hallucinations compared with the AD or FTD patients. The findings clearly demonstrate that AD, DLB, and FTD have distinctive neuropsychiatric features, which may correspond to different patterns of cerebral involvement characteristic of these three major degenerative dementias.

Key Words: Dementias (general) • Dementia, Frontotemporal • Alzheimer's Disease • Dementia With Lewy Bodies




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