Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by McCullagh, S. Articles by Feinstein, A. Search for Related Content PubMed Citation Articles by McCullagh, S. Articles by Feinstein, A. Other Mood Disorders

Treatment of Pathological Affect

Variability of Response for Laughter and Crying

Received April 30, 1999; revised July 16, 1999; accepted July 20, 1999. From the University of Toronto, Sunnybrook Hospital Site, Toronto, Ontario, Canada. Address correspondence to Dr. McCullagh, Neuropsychiatry Service, Sunnybrook Hospital, 2075 Bayview Avenue, Toronto, Ontario, Canada, M4N 3M5.

ABSTRACT

Pathological laughing and crying (PLC) is increasingly recognized to accompany diverse neurologic conditions, although it remains poorly understood. The authors describe 3 cases of amyotrophic lateral sclerosis (ALS) with an unusual change from a predominance of pathological crying to laughter following drug treatment. Possible explanations for this phenomenon are discussed.

Key Words: Amyotrophic Lateral Sclerosis • Laughter and Crying, Pathological

This article has been cited by other articles:

				H Kosaka, N Omata, M Omori, T Shimoyama, T Murata, K Kashikura, T Takahashi, J Murayama, Y Yonekura, and Y Wada Abnormal pontine activation in pathological laughing as shown by functional magnetic resonance imaging. J. Neurol. Neurosurg. Psychiatry, December 1, 2006; 77(12): 1376 - 1380. [Abstract] [Full Text] [PDF]

				R. Schiffer and L. E. Pope Review of Pseudobulbar Affect Including a Novel and Potential Therapy J Neuropsychiatry Clin Neurosci, November 1, 2005; 17(4): 447 - 454. [Abstract] [Full Text] [PDF]

				R. A Smith, J. E Berg, L. E Pope, J. D Callahan, D. Wynn, and R. A Thisted Validation of the CNS emotional lability scale for pseudobulbar affect (pathological laughing and crying) in multiple sclerosis patients Multiple Sclerosis, December 1, 2004; 10(6): 679 - 685. [Abstract] [PDF]

				M S Okun, D V Raju, B L Walter, J L Juncos, M R DeLong, K Heilman, W M McDonald, and J L Vitek Pseudobulbar crying induced by stimulation in the region of the subthalamic nucleus J. Neurol. Neurosurg. Psychiatry, June 1, 2004; 75(6): 921 - 923. [Abstract] [Full Text] [PDF]

				B. Wild, F. A. Rodden, W. Grodd, and W. Ruch Neural correlates of laughter and humour Brain, October 1, 2003; 126(10): 2121 - 2138. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2000 American Neuropsychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us