Cognitive Correlates of the Negative, Disorganized, and Psychotic Symptom Dimensions of Schizophrenia

doi:10.1176/appi.neuropsych.12.1.4



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	Schizophrenia Spectrum Disorders

J Neuropsychiatry Clin Neurosci 12:4-15, February 2000
© 2000 American Psychiatric Press, Inc.

Cognitive Correlates of the Negative, Disorganized, and Psychotic Symptom Dimensions of Schizophrenia

Daniel S. O'Leary, Ph.D., Michael Flaum, M.D., Marilyn L. Kesler, Laura A. Flashman, Ph.D., Stephan Arndt, Ph.D. and Nancy C. Andreasen, M.D., Ph.D.

Received July 14, 1998; revised August 18, 1999; accepted October 1, 1999. From the Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, Kentucky; Dartmouth Hitchcock Medical School, Lebanon, New Hampshire; and Department of Preventive Medicine and Environmental Health, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa. Address correspondence to Dr. O'Leary, the Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242.

Knowledge of the relationship between specific cognitive abnormalitiesand the clinical symptoms of schizophrenia could give insightinto the nature of their underlying pathophysiology. Compositescores were generated for negative, disorganized, and psychoticsymptom ratings in 134 patients with schizophrenia (DSM-IV criteria).Partial correlations (each composite corrected for the others)were computed with neuropsychological measures. Negative symptomswere related to poor performance on tests of verbal learningand memory, verbal fluency, visual memory, and visual-motorsequencing. Disorganized symptoms were correlated with lowerverbal IQ and poor concept attainment. Psychotic symptoms hadno significant relationship with cognitive deficit.

Key Words: Schizophrenia Spectrum Disorder • Cognition • Symptoms

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