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Treatment of Dementia-Associated Agitation With Gabapentin

Received March 16, 1999; revised July 13, 1999; accepted July 15, 1999. From the Department of Psychiatry and the Neurobehavior and Alzheimer's Disease Center, Beth Israel Medical Center, First Avenue at 16th Street, New York, NY 10003. Send correspondence to Dr. Roane at the above address.

The authors describe the use of gabapentin in the treatment of 4 outpatients with dementia-associated agitation. On the basis of clinical case reports and the Overt Agitation Severity Scale, all 4 patients had reduced agitation with gabapentin. Three of 4 patients were successfully titrated to a full dose of 2,400mg/day. These findings suggest a possible role for gabapentin in the behavioral management of patients with dementia.

Key Words: Gabapentin • Agitation • Dementia

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