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Clinical and Neuropsychological Profiles of Obsessive-Compulsive Schizophrenia

A Pilot Study

Received April 19, 1999; revised July 30, 1999; accepted August 24, 1999. From the Mental Health and Behavioral Sciences Service, Department of Veterans Affairs, New Jersey Health Care System, East Orange, New Jersey; Department of Psychiatry, Robert Wood Johnson Medical School, Piscataway, New Jersey; and Department of Neurosciences, UMDNJ-New Jersey Medical School, Newark, New Jersey. Address correspondence to Dr. Hwang, Department of Psychiatry (116A), East Orange VAMC, 385 Tremont Avenue, East Orange, NJ 07018.

ABSTRACT

This pilot study compared characteristics of obsessive-compulsive (OC) schizophrenic patients and a matched non-OC schizophrenic control group. The OC-schizophrenic group required more intensive clinical interventions and had a poorer clinical course, lower levels of functioning, and longer periods of hospitalization. They showed greater negative symptoms and more impaired executive functioning. These findings suggest OC-schizophrenic patients may have an atypical set of clinical and neuropsychiatric characteristics, perhaps constituting a subgroup within the schizophrenia spectrum. Pathophysiology and possible treatment implications require further study.

Key Words: Schizophrenia • Obsessive-Compulsive Symptoms

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