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Heritability Heightens Brain Metabolite Differences in Schizophrenia

Received April 1, 1999; revised August 27, 1999; accepted September 1, 1999. From the Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Kagoshima, Japan. Address correspondence to Dr. Fukuzako, Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan; e-mail: fukuzako{at}med4.kufm.kagoshima-u.ac.jp

ABSTRACT

Single-voxel proton magnetic resonance spectroscopy was performed in 64 medicated schizophrenic patients and 51 healthy subjects. Spectra were obtained from a voxel in the left medial temporal lobe by using a 2.0-tesla whole-body magnetic resonance imaging system. Schizophrenic patients showed a lower N-acetylaspartate/creatine-phosphocreatine ratio than did healthy subjects, and this reduction was greater in 13 patients with a family history of psychotic disorders.

Key Words: Proton Magnetic Resonance Spectroscopy • Schizophrenia • N-acetylaspartate

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