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Sertraline in the Treatment of Major Depression Following Mild Traumatic Brain Injury

Received June 22, 1999; revised July 30, 1999; accepted September 1, 1999. From the Department of Psychiatry and Behavioral Sciences, University of Washington, and the Department of Graduate Psychology, Seattle Pacific University, Seattle, Washington. Address correspondence to Dr. Fann, Department of Psychiatry and Behavioral Sciences, Box 356560, University of Washington, Seattle, WA 98195.

An 8-week, nonrandomized, single-blind, placebo run-in trial of sertraline was conducted on 15 patients diagnosed with major depression between 3 and 24 months after a mild traumatic brain injury. On the Hamilton Rating Scale for Depression, 13 (87%) had a decrease in score of 50% ("response"), and 10 (67%) achieved a score of 7 ("remission") by week 8 of sertraline. There was statistically significant improvement in psychological distress, anger and aggression, functioning, and postconcussive symptoms with treatment.

Key Words: Depression • Traumatic Brain Injury • Sertraline

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