J Neuropsychiatry Clin Neurosci 12:251-256, May 2000
© 2000 American Psychiatric Press, Inc.
Cognitive Performance in Relation to MRI Temporal Lobe Volume in Schizophrenic Patients and Healthy Control Subjects
Lydia Krabbendam, M.A.,
Mayke M. A. Derix, Ph.D.,
Adriaan Honig, M.D., Ph.D., M.R.C.Psych.,
Eric Vuurman, M.A.,
Rob Havermans, M.D.,
Jan T. Wilmink, Ph.D., M.D. and
Jellemer Jolles, Ph.D.
Received January 11, 1999; revised May 20, 1999; accepted May 26, 1999. From the Maastricht Brain and Behavior Institute, Department of Psychiatry and Neuropsychology, Maastricht University and Psychomedical Center Vijverdal, Maastricht; and Department of Radiology, University Hospital Maastricht, the Netherlands. Address correspondence to Dr. Krabbendam, Department of Psychiatry and Neuropsychology, Psychomedical Center Vijverdal, P.O. Box 88, 6200 AB Maastricht, the Netherlands.
The aim of this study was to identify whether specific deficits in cognitive processing are present in schizophrenia and whether these are related to the volume of temporal and limbic structures. Twenty-seven schizophrenic outpatients were compared with 19 matched control subjects. Compared with control subjects, patients performed complex tasks disproportionately worse than they performed simple tasks. No group differences were found with regard to temporal and limbic volume. Volume of the parahippocampal gyrus was correlated with cognitive performance. The findings are interpreted as evidence for a dysfunction in the maintenance of task-relevant information and the inhibition of irrelevant information.
Key Words: Schizophrenia • MRI Studies • Temporal Lobe
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