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Acquired Obsessive-Compulsive Disorder Associated With Basal Ganglia Lesions

Received July 15, 1999; revised October 1, 1999; accepted November 3, 1999. From the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, and The Methodist Hospital, Houston, Texas. Address correspondence to Dr. Chacko, The Methodist Hospital, 6560 Fannin, Suite 832, Houston, TX 77030.

ABSTRACT

The authors report 5 cases of acquired obsessive-compulsive disorder occurring later in life. Patients' presentations, which could be readily mistaken for a delusional disorder, were associated with depressive symptoms and basal ganglia lesions, implicating dysfunction of the cortical–basal ganglia–thalamic–cortical neuroanatomical circuit.

Key Words: Obsessive-Compulsive Disorder • Basal Ganglia

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