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Agitated Symptom Response to Divalproex Following Acute Brain Injury

Received August 10, 1999; revised January 10, 2000; accepted January 20, 2000. From the Department of Brain Injury Rehabilitation, Good Shepherd Rehabilitation Hospital, 501 St. John Street, Allentown, PA 18103-3296. Send correspondence to Dr. Showalter at the above address.

ABSTRACT

This is the largest case series (N=29) to date describing divalproex for agitation symptoms. Chart information was abstracted retrospectively for all patients who received divalproex for agitation symptoms during a 22-month period in one inpatient brain injury rehabilitation unit. For 26 patients (90%), divalproex appeared effective within 7 days after a typical 1,250 mg/day dose. Most patients (93%) were discharged to their home or community sites. Divalproex appears to be an efficacious alternative to neuroleptics and benzodiazepines for alert, labile, impulsive, and disinhibited brain injury patients.

Key Words: Traumatic Brain Injury • Agitation • Divalproex

This article has been cited by other articles:

				E. Kim and T. J. Humaran Divalproex in the Management of Neuropsychiatric Complications of Remote Acquired Brain Injury J Neuropsychiatry Clin Neurosci, May 1, 2002; 14(2): 202 - 205. [Abstract] [Full Text] [PDF]

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