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A Volumetric Study of Hippocampus and Amygdala in Depressed Patients With Subjective Memory Problems

Received August 27, 1999; revised February 11, 2000; accepted March 21, 2000. From the National Hospital for Neurology and Neurosurgery and the University Department of Clinical Neurology, Institute of Neurology, Queen Square, London. Address correspondence to Dr. Ron, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom.

MRI was used to measure amygdalar and hippocampal volumes in 14 nondemented depressed patients who persistently complained of "memory" difficulties and in 14 control subjects. Mild neuropsychological impairment had been detected in 5 patients before the study but had later improved. The volume of the left amygdala was smaller in depressed subjects, and there was a trend for smaller left hippocampus in the 5 patients who had exhibited mild cognitive impairment. The authors conclude that subjective memory complaints in depressed patients do not translate into a clinical picture of dementia, but that abnormalities in the amygdala and hippocampus may be relevant in explaining affective and cognitive symptoms.

Key Words: Depression • Memory • MRI Studies

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