J Neuropsychiatry Clin Neurosci 13:42-49, February 2001
© 2001 American Psychiatric Press, Inc.
Neuropsychiatric Symptoms of Patients With Progressive Supranuclear Palsy and Parkinson's Disease
Dag Aarsland, M.D., Ph.D.,
Irene Litvan, M.D. and
Jan P. Larsen, M.D., Ph.D.
Received February 17, 2000; revised May 22, 2000; accepted May 31, 1999. From the Section of Geriatric Psychiatry, Rogaland Psychiatric Hospital, Norway; Cognitive Neuropharmacology Unit, Defense and Veteran Head Injury Program, Henry M. Jackson Foundation, Bethesda, Maryland; and Department of Neurology, Central Hospital of Rogaland, Stavanger, Norway. Address correspondence to Dr. Aarsland, Section of Geriatric Psychiatry, Rogaland Psychiatric Hospital, PO Box 1163 Hillevåg, N-4004 Stavanger, Norway. E-mail: aarsland{at}netpower.no
Neuropsychiatric symptoms are common in basal ganglia disorders and may have severe clinical consequences. The authors compared the neuropsychiatric manifestations of patients with Parkinson's disease (PD) and progressive supranuclear palsy (PSP). All 103 PD patients and 27 of the 61 PSP patients were taking dopaminergic agents. PSP patients showed significantly more apathy and disinhibition. Patients with PD had higher frequency of hallucinations, delusions, and depression. These results suggest that PSP patients show symptoms compatible with lesioned orbitofrontal and medial frontal circuits, such as disinhibition and apathy, whereas PD patients show symptoms associated with monoaminergic disturbances, such as psychosis and depression.
Key Words: Parkinson's Disease • Progressive Supranuclear Palsy
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