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Depression Does Not Influence Basal Ganglia–Mediated Psychomotor Speed in HIV-1 Infection

Received August 24, 1999; revised February 7, 2000; accepted May 10, 2000. From the Department of Neurology, Heinrich Heine University, Duesseldorf, Germany. Address correspondence to Dr. H.J.v. Giesen, Department of Neurology, Heinrich Heine University of Duesseldorf, Postfach 10 10 07, D-40001 Duesseldorf, Germany. E-mail: giesenhj{at}uni-duesseldorf.de

The authors examined the effects of depressive mood (Hamilton Rating Scale for Depression [Ham-D]) on basal ganglia–mediated psychomotor speed (motor test battery) in 202 HIV-1 seropositive homosexual males with no prior history of antiretroviral treatment. HIV-1 seropositive patients showed a significant slowing of most rapid alternating movements (MRAM) and significantly prolonged contraction times (CT) compared with 66 HIV-1 seronegative male control subjects. Factor analysis of Ham-D scores isolated a factor containing the items depressed mood, suicide, and psychic and somatic anxiety. This factor did not correlate with MRAM or CT. Depression and psychomotor speed are independent in HIV-1infection.

Key Words: HIV/AIDS • Depression

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