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EEG Monitoring in Depressed Patients Undergoing Repetitive Transcranial Magnetic Stimulation

Received March 15, 2000; revised June 27, 2000; accepted September 7, 2000. From the Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut. Address correspondence to Dr. Boutros, 950 Campbell Avenue (116A), West Haven, CT 06516. E-mail: nash.Boutros{at}yale.edu

To date, 33 subjects diagnosed with major depressive disorder have undergone transcranial magnetic stimulation (TMS) in the authors' clinic. Five of these patients showed minimal electroencephalogram (EEG) variants at baseline. The authors describe the course of treatment and serial EEGs in 3 of the 5 patients who did not show progressive EEG changes in association with active rTMS. These three cases suggest that minimal EEG anomalies at baseline need not serve as a contraindication to undergoing rTMS. Two patients with progressive EEG changes in association with sham rTMS in one and active rTMS in the other are also discussed.

Key Words: Seizures • Electroencephalography (EEG) • Transcranial Magnetic Stimulation (TMS)

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