Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Hinkin, C. H. Articles by Singer, E. Search for Related Content PubMed Citation Articles by Hinkin, C. H. Articles by Singer, E. AIDS/HIV

Methylphenidate Improves HIV-1–Associated Cognitive Slowing

Received April 19, 2000; revised July 19, 2000; accepted July 31, 2000. From the Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine; Veterans Affairs Greater Los Angeles Health Care System; and Department of Neurology, UCLA School of Medicine, Los Angeles, California. Address correspondence to Dr. Hinkin, Department of Psychiatry, UCLA School of Medicine, 760 Westwood Plaza, Room C8–747, Los Angeles, CA 90024. E-mail: chinkin{at}ucla.edu

Sixteen HIV-1 seropositive individuals participated in a single-blind, placebo-controlled, crossover-design study of the effectiveness of 30 mg/ day of methylphenidate (MPH) in the treatment of HIV-associated cognitive slowing. Regression analyses revealed that participants who entered the study with a greater degree of either depressive symptomatology or cognitive slowing tended to demonstrate a better response to MPH on computerized measures of choice and dual-task reaction time. Participants without evidence of cognitive slowing at study entry did not show greater improvement on MPH than on placebo. Contrary to expectation, symptoms of depression did not respond better to MPH than to placebo, regardless of initial symptomatology. Information processing slowing in HIV-1 infection therefore appears amenable to pharmacologic intervention with the dopamine agonist MPH. However, results suggest clinicians should consider reserving the use of MPH for patients with more pronounced cognitive and affective deficits.

Key Words: Methylphenidate • AIDS/HIV • Neuropsychology

This article has been cited by other articles:

				G.-J. Wang, L. Chang, N. D. Volkow, F. Telang, J. Logan, T. Ernst, and J. S. Fowler Decreased brain dopaminergic transporters in HIV-associated dementia patients Brain, November 1, 2004; 127(11): 2452 - 2458. [Abstract] [Full Text] [PDF]

				I. F. Tannock, T. A. Ahles, P. A. Ganz, and F. S. van Dam Cognitive Impairment Associated With Chemotherapy for Cancer: Report of a Workshop J. Clin. Oncol., June 1, 2004; 22(11): 2233 - 2239. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2001 American Neuropsychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us