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Specific Frontal Lobe Subregions Correlated With Unawareness of Illness in Schizophrenia

A Preliminary Study

Received January 11, 2000; revised July 12, 2000; accepted July 31, 2000. From the Department of Psychiatry, Neuropsychiatry Section, and Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, New Hampshire; and the New Hampshire Hospital, Concord, New Hampshire. Address correspondence to Dr. Flashman, Department of Psychiatry, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756. E-mail: flashman{at}dartmouth.edu

ABSTRACT

The authors examined the relationship between unawareness of illness and eight frontal lobe subregions in 15 patients with schizophrenia. Significant inverse correlations were seen between unawareness and bilateral middle frontal gyrus volume and between symptom misattribution and superior frontal gyrus volume.

Key Words: Frontal Lobes • Schizophrenia • Anosognosia

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