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J Neuropsychiatry Clin Neurosci 13:258-260, May 2001
© 2001 American Psychiatric Press, Inc.


Clinical and Research Reports

Dentatorubral-Pallidoluysian Atrophy (DRPLA) Presenting With Psychosis

Naoto Adachi, M.D., Kunimasa Arima, M.D., Takashi Asada, M.D., Masaaki Kato, M.D., Narihiro Minami, M.D., Yu-ichi Goto, M.D., Teiichi Onuma, M.D., Takeshi Ikeuchi, M.D., Shoji Tsuji, M.D., Masahiro Hayashi, M.D. and Yuken Fukutani, M.D.

Received April 7, 2000; revised August 16, 2000; accepted September 7, 2000. From the National Center of Neurology and Psychiatry, Kodaira, Japan; Adachi Mental Clinic, Sapporo; Tokyo Institute of Psychiatry, Tokyo; Department of Neurology, Brain Research Institute, Niigata University, Niigata; National Hokuriku Hospital, Joana; and Department of Neuropsychiatry, Fukui Medical University, Fukui, Japan. Address correspondence to Dr. Adachi, Adachi Mental Clinic, Kitano 7-5-12-40, Kiyota, Sapporo 004-0867, Japan. E-mail: adacchan{at}tky2.3web.ne.jp

ABSTRACT

The authors report on four DRPLA patients who manifested delusions. All patients demonstrated autosomal dominant DRPLA confirmed by standard gene analysis. Patients with DRPLA can exhibit a variety of psychiatric symptoms in addition to extrapyramidal and cerebellar symptoms.

Key Words: Dentatorubral-Pallidoluysian Atrophy (DRPLA) • Psychosis • Gene Analysis







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