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The Relationship of Akathisia With Suicidality and Depersonalization Among Patients With Schizophrenia

E. Cem Atbaoglu, M.D., Susan K. Schultz, M.D. and Nancy C. Andreasen, M.D., Ph.D.

Received June 7, 2000; revised September 12, 2000; accepted October 19, 2000. From Ankara University, Department of Psychiatry, Ankara, Turkey; and the University of Iowa, Mental Health Clinical Research Center, Iowa City, Iowa. Address correspondence to Dr. Atbaoglu, Ankara Üniversitesi, Tip Fakltesi, Psikiyatri Anabilim Dali, Dikimevi, Ankara, 06100, Turkey. E-mail: atbasoglu{at}superonline.com

An association of suicidality and depersonalization with akathisia has been reported, but it is not clear whether these phenomena are specific to akathisia or are nonspecific manifestations of distress. The authors used the Barnes Akathisia Rating Scale, Brief Psychiatric Rating Scale, and Hamilton Rating Scale for Depression (Ham-D) to examine the relationships between suicidality, depersonalization, dysphoria, and akathisia in 68 patients with schizophrenia or schizophreniform disorder. Akathisia was associated with higher scores on the Ham-D ratings of suicidality, depersonalization, and agitation. In a logistic regression model, depressive mood and subjective awareness of akathisia appeared to be the only predictors of suicidality and depersonalization, respectively. These findings support the association between akathisia and both suicidality and depersonalization. However, these symptoms appear to be nonspecific responses to accompanying depressive mood and the subjective awareness of the akathisia syndrome, respectively.

Key Words: Akathisia • Suicidality • Depersonalization

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