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Neuroactive Steroid Levels in Patients With Generalized Anxiety Disorder

Received June 14, 2000; revised September 13, 2000; accepted September 20, 2000. From the Department of Psychiatry, 1E1.01 Mackenzie Centre, University of Alberta Hospital, Edmonton, Alberta, T6G 2B7, Canada. Address correspondence to Dr. Semeniuk. E-Mail: tsemeniu{at}ualberta.ca

ABSTRACT

Serum levels of allopregnanolone, pregnenolone sulfate, and dehydroepiandrosterone sulfate were measured in 8 male patients with generalized anxiety disorder (GAD) and 8 healthy control subjects. Results suggest that patients with GAD have significantly lower levels of pregnenolone sulfate than control subjects.

Key Words: Steroids, Neuroactive • Anxiety

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