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Subtle Prefrontal Neuropathology in a Pilot Magnetic Resonance Spectroscopy Study in Patients With Borderline Personality Disorder

Received April 13, 2001; revised June 20, 2001; accepted June 27, 2001. From the Department of Psychiatry and Psychotherapy and Department of Radiology, Albert-Ludwigs-University, Freiburg, Germany. Address correspondence to Dr. Tebartz van Elst, Department of Psychiatry and Psychotherapy, Hauptstr. 5; 79104 Freiburg - Germany. E-mail: ludger_vanelst{at}psyallg.ukl.uni-freiburg.de

ABSTRACT

The authors examined the brains of patients with borderline personality disorder (BPD) by using short echo time single voxel spectroscopy and found a significant 19% reduction of absolute N-acetylaspartate concentrations in the dorsolateral prefrontal cortex in BPD (P=0.01) compared with control subjects.

Key Words: Personality Disorder, Borderline • Magnetic Resonance Spectroscopy • Frontal Lobe

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