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Age and Regional Cerebral Blood Flow in Schizophrenia

Age Effects in Anterior Cingulate, Frontal, and Parietal Cortex

Received July 26, 2000; revised December 7, 2000; accepted December 18, 2000. From the Mental Health Clinical Research Center and the Departments of Radiology and Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa. Address correspondence to Dr. Schultz, Psychiatry Research, 1-189A MEB, University of Iowa College of Medicine, Iowa City, IA 52242-1000. E-mail: Susan-schultz{at}uiowa.edu

Positron emission tomography ([¹⁵O] water PET) was used to examine the relationship between age and regional cerebral blood flow (rCBF) in schizophrenia. Forty-nine unmedicated male patients, ages 20–51, underwent imaging during an eyes-closed resting condition. Negative correlations were observed between age and rCBF in the anterior cingulate, as well as in frontal (Brodmann area 8) and parietal cortex (area 40) bilaterally. The observation of reduced rCBF in the anterior cingulate with increased age is consistent with previous findings in healthy subjects. In contrast, the reduced flow observed in the frontal and parietal regions may be unique to schizophrenia.

Key Words: Schizophrenia • PET Studies • Geriatric Neuropsychiatry

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