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Effects of Depression and Parkinson's Disease on Cognitive Functioning

Received September 15, 1999; revised January 20, 2001; accepted January 26, 2001. From the Department of Psychology, Xavier University, Cincinnati, Ohio; Departments of Psychiatry and Behavioral Sciences and of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington; and Veterans Affairs Medical Center, Kansas City, Missouri. Address correspondence to Dr. Norman, Psychology Department, Xavier University, 3800 Victory Parkway, Cincinnati, OH 45207–6511.

This study compared the performance of Parkinson's disease (PD) patients with and without depression, patients with depression alone, and normal control subjects on a cognitive screening instrument, the Mattis Dementia Rating Scale (DRS) to evaluate the influences of depression and Parkinson's disease on cognition. PD affects overall level of cognitive functioning and, to a lesser extent, DRS Initiation/Perseveration, Construction, and Attention. Diminished memory was primarily related to depression. Treatment of depression may ameliorate aspects of cognitive dysfunction in the PD patient with depression.

Key Words: Depression • Parkinson's Disease • Cognition

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