J Neuropsychiatry Clin Neurosci 14:44-51, February 2002
© 2002 American Psychiatric Press, Inc.
Frontal Cortex Atrophy Predicts Cognitive Impairment in Multiple Sclerosis
Ralph H.B. Benedict, Ph.D.,
Rohit Bakshi, M.D.,
Jack H. Simon, M.D., Ph.D.,
Roger Priore, Sc.D.,
Colleen Miller, D.N.S. and
Frederick Munschauer, M.D.
Received September 1, 2000; revised November 21, 2000; accepted November 27, 2000. From the Department of Neurology, State University of New York at Buffalo School of Medicine, Buffalo, New York, and the University of Colorado Health Sciences Center, Denver, Colorado. Address correspondence to Dr. Benedict, Neurology, Suite D-6, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203. E-mail: benedict{at}acsu.buffalo.edu
The association between regional measures of cortical atrophy and neuropsychological (NP) dysfunction was studied in 35 multiple sclerosis (MS) patients. Patients underwent neurological examination, MRI, and NP testing. Blind quantitative MRI analysis yielded total T2 lesion area (TLA) and third ventricle width (3VW). Cortical atrophy, rated by blind visual inspection, was more extensive in superior frontal and parietal cortices than in other regions. No MRI measures were correlated with depression scores. TLA and 3VW were significantly correlated with each NP test. Cortical atrophy measures for bilateral superior frontal cortex were retained in regression models predicting impairments in verbal learning, spatial learning, attention, and conceptual reasoning. The authors conclude that cerebral atrophy predicts NP impairment while accounting for the influence of TLA or 3VW. Regions of cortex most susceptible to atrophic and cognitive changes in MS are the right and left superior frontal lobes.
Key Words: Magnetic Resonance Imaging • Dementia • Multiple Sclerosis
This article has been cited by other articles:
|
|
|
|
 
M. P. Amato, E. Portaccio, B. Goretti, V. Zipoli, M. Battaglini, M. L. Bartolozzi, M. L. Stromillo, L. Guidi, G. Siracusa, S. Sorbi, et al.
Association of Neocortical Volume Changes With Cognitive Deterioration in Relapsing-Remitting Multiple Sclerosis
Arch Neurol,
August 1, 2007;
64(8):
1157 - 1161.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. H.B. Benedict, J. Bruce, M. G. Dwyer, B. Weinstock-Guttman, C. Tjoa, E. Tavazzi, F. E. Munschauer, and R. Zivadinov
Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis
Multiple Sclerosis,
July 1, 2007;
13(6):
722 - 730.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B A Parmenter, B Weinstock-Guttman, N Garg, F Munschauer, and R H. Benedict
Screening for cognitive impairment in multiple sclerosis using the Symbol Digit Modalities Test
Multiple Sclerosis,
January 1, 2007;
13(1):
52 - 57.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. Bo, J. J. G. Geurts, P. van der Valk, C. Polman, and F. Barkhof
Lack of Correlation Between Cortical Demyelination and White Matter Pathologic Changes in Multiple Sclerosis
Arch Neurol,
January 1, 2007;
64(1):
76 - 80.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Dalton, K. A. Miszkiel, P. W. O'Connor, G. T. Plant, G.P.A. Rice, and D. H. Miller
Ventricular enlargement in MS: One-year change at various stages of disease
Neurology,
March 14, 2006;
66(5):
693 - 698.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. H. B. Benedict, R. Zivadinov, D. A. Carone, B. Weinstock-Guttman, J. Gaines, C. Maggiore, J. Sharma, M.-A. Tomassi, and R. Bakshi
Regional Lobar Atrophy Predicts Memory Impairment in Multiple Sclerosis
AJNR Am. J. Neuroradiol.,
August 1, 2005;
26(7):
1824 - 1831.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R F Brown, C C Tennant, S M Dunn, and J D Pollard
A review of stress-relapse interactions in multiple sclerosis: important features and stress-mediating and -moderating variables
Multiple Sclerosis,
August 1, 2005;
11(4):
477 - 484.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M S A Deloire, E Salort, M Bonnet, Y Arimone, M Boudineau, H Amieva, B Barroso, J-C Ouallet, C Pachai, E Galliaud, et al.
Cognitive impairment as marker of diffuse brain abnormalities in early relapsing remitting multiple sclerosis
J. Neurol. Neurosurg. Psychiatry,
April 1, 2005;
76(4):
519 - 526.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Goverover, N. Chiaravalloti, and J. DeLuca
The relationship between self-awareness of neurobehavioral symptoms, cognitive functioning, and emotional symptoms in multiple sclerosis
Multiple Sclerosis,
April 1, 2005;
11(2):
203 - 212.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Pagani, M. A. Rocca, A. Gallo, M. Rovaris, V. Martinelli, G. Comi, and M. Filippi
Regional Brain Atrophy Evolves Differently in Patients with Multiple Sclerosis According to Clinical Phenotype
AJNR Am. J. Neuroradiol.,
February 1, 2005;
26(2):
341 - 346.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Locatelli, R. Zivadinov, A. Grop, and M. Zorzon
Frontal parenchymal atrophy measures in multiple sclerosis
Multiple Sclerosis,
October 1, 2004;
10(5):
562 - 568.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A Bruck, T Kurki, V Kaasinen, T Vahlberg, and J O Rinne
Hippocampal and prefrontal atrophy in patients with early non-demented Parkinson's disease is related to cognitive impairment
J. Neurol. Neurosurg. Psychiatry,
October 1, 2004;
75(10):
1467 - 1469.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Zarei, S Chandran, A Compston, and J Hodges
Cognitive presentation of multiple sclerosis: evidence for a cortical variant
J. Neurol. Neurosurg. Psychiatry,
July 1, 2003;
74(7):
872 - 877.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Christodoulou, L. B. Krupp, Z. Liang, W. Huang, P. Melville, C. Roque, W. F. Scherl, T. Morgan, W. S. MacAllister, L. Li, et al.
Cognitive performance and MR markers of cerebral injury in cognitively impaired MS patients
Neurology,
June 10, 2003;
60(11):
1793 - 1798.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 2002
American Neuropsychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
