Apolipoprotein E Gender Effects on Cognitive Performance in Age-Associated Memory Impairment

doi:10.1176/appi.neuropsych.14.1.80



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	General Topics in Psychiatry

J Neuropsychiatry Clin Neurosci 14:80-83, February 2002
© 2002 American Psychiatric Press, Inc.

Clinical and Research Reports

Apolipoprotein E Gender Effects on Cognitive Performance in Age-Associated Memory Impairment

David Bartrés-Faz, Ph.D., Carme Junqué, Ph.D., Pedro Moral, Ph.D., Antoni López-Alomar, M.S., Josep Sánchez-Aldeguer, M.D. and Imma C. Clemente, Ph.D.

Received May 31, 2000; revised February 1, 2000; accepted February 5, 2001. From the Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Catalunya, Spain. Address correspondence to Dr. Bartrés-Faz, Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, IDiBAPS asamova 143, 08036, Barcelona, Spain. E-mail: dbartres{at}psi.ub.es

ABSTRACT

Among 100 individuals with age-associated memory impairment(AAMI), APOE E4 carriers performed worse on memory. However,when subjects were considered by gender, this effect was onlyobserved in females. APOE E4 may have a more robust cognitiveinfluence on female than on male individuals with AAMI.

Key Words: Genes • Memory • Geriatric Neuropsychiatry

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