Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Rosenberg, P. B. Articles by Balish, M. Search for Related Content PubMed Citation Articles by Rosenberg, P. B. Articles by Balish, M. Depression

Repetitive Transcranial Magnetic Stimulation Treatment of Comorbid Posttraumatic Stress Disorder and Major Depression

Received March 12, 2001; revised June 12, 2001; accepted June 18, 2001. From the Mental Health Service Line (R.B.M., P.B.R., R.B.R.) and Neurology Service (M.B., Y.P.M., A.W.), Department of Veterans Affairs Medical Center; Georgetown University School of Medicine (M.B., P.B.R., R.B.R.); and Howard University School of Medicine (Y.P.M.), Washington, DC. Address correspondence to Dr. Rosenberg, MHSL #116A, DVAMC Washington DC, 50 Irving Street, N.W., Washington, DC 20422. E-mail: paul.rosenberg{at}med.va.gov

Twelve patients with comorbid posttraumatic stress disorder (PTSD) and major depression underwent repetitive transcranial magnetic stimulation (rTMS) to left frontal cortex as an open-label adjunct to current antidepressant medications. rTMS parameters were as follows: 90% of motor threshold, 1 Hz or 5 Hz, 6,000 stimuli over 10 days. Seventy-five percent of the patients had a clinically significant antidepressant response after rTMS, and 50% had sustained response at 2-month follow-up. Comparable improvements were seen in anxiety, hostility, and insomnia, but only minimal improvement in PTSD symptoms. Left frontal cortical rTMS may have promise for treating depression in PTSD, but there may be a dissociation between treating mood and treating core PTSD symptoms.

Key Words: Depression • Posttraumatic Stress Disorder • Repetitive Transcranial Magnetic Stimulation

This article has been cited by other articles:

				D. J.L.G. Schutter, J. S. Peper, H. P.F. Koppeschaar, R. S. Kahn, and J. van Honk Administration of Testosterone Increases Functional Connectivity in a Cortico-Cortical Depression Circuit J Neuropsychiatry Clin Neurosci, August 1, 2005; 17(3): 372 - 377. [Abstract] [Full Text] [PDF]

				D. J.L.G. Schutter, A. A.L. d'Alfonso, and J. van Honk Counterintuitive Antidepressant Properties of Slow rTMS Over the Left Frontal Cortex: A Possible Mechanism J Neuropsychiatry Clin Neurosci, May 1, 2003; 15(2): 243 - 244. [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2002 American Neuropsychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us