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Disease-Specific Properties of the Hamilton Rating Scale for Depression in Patients With Stroke, Alzheimer's Dementia, and Parkinson's Disease

Received October 31, 2000; revised May 1, 2001; accepted May 8, 2001. From the Department of Psychiatry, University Medical Center Nijmegen (P.N.); Department of Psychiatry, Maastricht University Hospital (A.F.G.L., F.R.J.V.); and Department of Neurology, University Hospital Rotterdam (F.V.K.), The Netherlands. Address correspondence to Dr. Naarding, Department of Psychiatry, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. E-mail: p.naarding{at}czzopsy.azn.nl

To compare the psychometric properties of the Hamilton Rating Scale for Depression (Ham-D) in patients with stroke, Alzheimer's dementia (AD), and Parkinson's disease (PD), receiver operating characteristic curves were plotted for each group. The concurrent validity of the Ham-D with the DSM-IV criteria for major depressive disorder was high in each of these groups. However, optimal performance of the Ham-D requires the application of disease-specific cutoff scores for screening, diagnostic, and dichotomization purposes. These disease-specific cutoff scores were highest in PD, lower in AD, and lowest in stroke patients.

Key Words: Depression • Parkinson's Disease • Alzheimer's Disease • Stroke • Rating Instruments • Depression

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