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Traumatic Brain Injury and Atrophy of the Cingulate Gyrus

Received December 13, 2000; revised May 10, 2001; accepted May 18, 2001. From the Department of Psychology, University of San Francisco, San Francisco, California (R.Y.); Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois (K.A.R.); Department of Biology, University of Maryland, College Park, Maryland (M.B.); Psychology Department, Brigham Young University, Provo, Utah (D.F.T., M.J.M., T.A., P.G., R.O.H., E.D.B.); and Department of Physical Medicine and Rehabilitation, LDS Hospital, Salt Lake City, Utah (D.R., R.O.H., E.D.B.). Address correspondence to Dr. Bigler, Psychology Department, 1001 SWKT, Brigham Young University, Provo, UT 84602. E-mail: erin_bigler{at}byu.edu

The medial surface areas of the cingulate gyrus (CG) and other midline structures (corpus callosum, thalamus, lateral ventricle) were examined in 27 traumatically brain injured (TBI) and 12 age- and gender-matched control subjects from an established TBI data base. Significant atrophy, primarily in the posterior CG, was found in TBI patients. Degree of atrophy was related to severity of injury. TBI subjects also had significantly reduced corpus callosum and thalamic cross-sectional surface areas with associated increased lateral ventricular volume, as well as reduced brain volume and increased ventricle-to-brain ratio. Despite significant atrophy of the posterior CG, neuropsychological performance was not related to changes in CG cross-sectional surface area in the TBI subjects. This apparent discrepancy is discussed.

Key Words: Traumatic Brain Injury • Cingulate Gyrus • Atrophy

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