J Neuropsychiatry Clin Neurosci 14:424-429, November 2002
© 2002 American Psychiatric Press, Inc.
Neuropsychiatric Features of Frontotemporal Dementia
Evaluation of Consensus Criteria and Review
Mario F. Mendez, M.D., Ph.D. and
Kent M. Perryman, Ph.D.
Received April 4, 2001; revised August 6, 2001; accepted August 21, 2001. From the Departments of Neurology and Psychiatry & Biobehavioral Sciences, UCLA School of Medicine. Address correspondence to Dr. Mendez, Neurobehavior Unit (116AF), V.A. Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, CA 90073. E-mail: mmendez{at}UCLA.edu
Neuropsychiatric features characterize frontotemporal dementia (FTD). The authors evaluated the neuropsychiatric features of 53 FTD patients and retrospectively applied the Consensus Criteria for this disorder. Only one-third of the patients met Consensus Criteria for FTD on presentation. Most had early disengagement with poor insight; however, more than half retained socially appropriate interpersonal conduct and emotional expression. Supportive features, including compulsive-like acts and speech changes, were common presenting features, and 20% developed the Klüver-Bucy syndrome on 2-year follow-up. Consensus Criteria for FTD offer guidelines for diagnosis, but further refinement is needed, particularly for patients who lack early changes in social interpersonal conduct.
Key Words: Dementia • Frontal Lobe • Diagnostic Criteria
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