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Clinical Features and Comorbidity of Mood Fluctuations in Parkinson's Disease

Received July 10, 2001; accepted September 18, 2001. From the Departments of Neurology & Neurological Surgery (B.A.R., J.W.M., J.S.P., K.J.B.), Anatomy & Neurobiology (J.W.M., J.S.P.), Pediatrics (J.W.M.), and Psychiatry (J.M.H., T.H., K.J.B.) and the Mallinckrodt Institute of Radiology (J.S.P., K.J.B.), Washington University School of Medicine, St. Louis, Missouri; and the American Parkinson Disease Association Advanced Center for Parkinson Research (all authors). Address correspondence to Dr. Racette, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110. E-mail: racetteb{at}neuro.wustl.edu

Parkinson's disease (PD) patients commonly develop fluctuations in their motor responses to levodopa within several years of initiation of treatment; some also develop nonmotor fluctuations. The authors performed a case-control study comparing the frequency of comorbid symptoms in 70 PD patients who experienced clinically apparent mood changes during their motor "on" or "off" states with two control groups with no mood fluctuations. Mood fluctuators had significantly younger age at onset and longer disease duration and were significantly more likely to have dementia, psychosis, clinical depression, and motor complications. This association remained after removing effects of age and disease duration.

Key Words: Parkinson's Disease

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				K. J. Black, T. Hershey, J. M. Koller, T. O. Videen, M. A. Mintun, J. L. Price, and J. S. Perlmutter A possible substrate for dopamine-related changes in mood and behavior: Prefrontal and limbic effects of a D3-preferring dopamine agonist PNAS, December 24, 2002; 99(26): 17113 - 17118. [Abstract] [Full Text] [PDF]

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