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A Magnetization Transfer Analysis of the Thalamus in Schizophrenia

Received February 22, 2001; revised June 6, 2001; accepted June 23, 2001. From the Institute of Neurology, University College London (M.S.B., J.F., G.d.B., G.J.B., D.H.M., M.A.R.), and Imperial College School of Medicine, Charing Cross Campus (M.M.), London, UK. Address correspondence to Dr. Bagary, Section of Neuropsychiatry and NMR Research Unit, Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, United Kingdom. E-mail: m.bagary{at}ion.ucl.ac.uk

The authors investigated the thalamus in schizophrenia by using magnetization transfer ratio (MTR), a novel structural magnetic resonance technique sensitive to subtle neuropathological abnormalities. The dorsomedial nucleus (DMN) and pulvinar were selected because of their connections to limbic, prefrontal, and temporal regions, putatively relevant in schizophrenia. Volume (intracranial; thalamic) and MTR (whole thalamus; DMN; pulvinar) were determined in 25 patients with chronic schizophrenia by DSM-IV criteria and 25 control subjects. There were no significant differences between patients and control subjects in thalamic volume (corrected for intracranial volume) or MTR in whole thalamus, DMN, or pulvinar. No volumetric or MTR abnormalities could be detected in the thalamus of patients with schizophrenia. The findings suggest that abnormalities, if present, are very subtle and beyond the power of resolution of these techniques.

Key Words: Schizophrenia • Thalamus • Neuroimaging, Structural • Magnetization Transfer Analysis

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