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Association of Obsessions and Compulsions in Schizophrenia With Neurocognition and Negative Symptoms

Received November 20, 2000; revised May 10, 2001; accepted May 30, 2001. From Roudebush VA Medical Center and the Indiana University School of Medicine, Indianapolis, Indiana (P.H.L.); West Haven VA Medical Center, West Haven, Connecticut (G.J.B., T.C.G., M.D.B.); Indiana University–Purdue University, Indianapolis, Indiana (K.A.M.); and Yale University School of Medicine, New Haven, Connecticut (M.D.B.). Address correspondence to Dr. Lysaker, Day Hospital 116H, 1481 West 10th Street, Roudebush VA Medical Center, Indianapolis, IN 46202. E-mail: Lysaker.Paul_H_PHD{at}Indianapolis.va.gov

It is unclear whether obsessions and compulsions in schizophrenia spectrum disorders are associated with a unique pattern of symptoms and deficits. Accordingly, the present study compared symptom levels and neurocognitive function of participants with schizophrenia or schizoaffective disorder with (n=11) and without (n=52) significant obsessive-compulsive symptoms. Analyses of variance revealed that the obsessive-compulsive group performed more poorly on measures of executive function and vigilance and had higher levels of negative and emotional discomfort symptoms. Unexpectedly, the obsessive-compulsive group also demonstrated superior performance on a measure of visual memory. The implications of these clinical correlates of obsessive-compulsive phenomena in schizophrenia spectrum disorders are discussed.

Key Words: Schizophrenia Spectrum Disorders • Obsessive-Compulsive Disorder and Symptoms • Negative Symptoms

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