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* Neuropsychology
* Obsessive-Compulsive Disorder
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J Neuropsychiatry Clin Neurosci 14:449-453, November 2002
© 2002 American Psychiatric Press, Inc.

Association of Obsessions and Compulsions in Schizophrenia With Neurocognition and Negative Symptoms

Paul H. Lysaker, Ph.D., Gary J. Bryson, Psy.D., Kriscinda A. Marks, M.S., Tamasine C. Greig, Ph.D. and Morris D. Bell, Ph.D.

Received November 20, 2000; revised May 10, 2001; accepted May 30, 2001. From Roudebush VA Medical Center and the Indiana University School of Medicine, Indianapolis, Indiana (P.H.L.); West Haven VA Medical Center, West Haven, Connecticut (G.J.B., T.C.G., M.D.B.); Indiana University–Purdue University, Indianapolis, Indiana (K.A.M.); and Yale University School of Medicine, New Haven, Connecticut (M.D.B.). Address correspondence to Dr. Lysaker, Day Hospital 116H, 1481 West 10th Street, Roudebush VA Medical Center, Indianapolis, IN 46202. E-mail: Lysaker.Paul_H_PHD{at}Indianapolis.va.gov

It is unclear whether obsessions and compulsions in schizophrenia spectrum disorders are associated with a unique pattern of symptoms and deficits. Accordingly, the present study compared symptom levels and neurocognitive function of participants with schizophrenia or schizoaffective disorder with (n=11) and without (n=52) significant obsessive-compulsive symptoms. Analyses of variance revealed that the obsessive-compulsive group performed more poorly on measures of executive function and vigilance and had higher levels of negative and emotional discomfort symptoms. Unexpectedly, the obsessive-compulsive group also demonstrated superior performance on a measure of visual memory. The implications of these clinical correlates of obsessive-compulsive phenomena in schizophrenia spectrum disorders are discussed.

Key Words: Schizophrenia Spectrum Disorders • Obsessive-Compulsive Disorder and Symptoms • Negative Symptoms




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