J Neuropsychiatry Clin Neurosci 15:53-57, February 2003
© 2003 American Psychiatric Press, Inc.
No Evidence of a Homogeneous Frontal Neuropsychological Profile in a Sample of Schizophrenic Subjects
Orsola Gambini, M.D.,
Arturo Campana, M.D.,
Giacomo Garghentini, Ph.D. and
Silvio Scarone, M.D.
Received June 7, 2001; revised November 14, 2001; accepted December 4, 2001. From the Psychiatric Branch, Department of Medicine, Surgery, and Dentistry, University of Milan Medical School and S. Paolo Hospital, Via A. di Rudinì 8, 20142 Milan, Italy. Address correspondence to Dr. Gambini.
The authors obtained a frontal functions profile for 81 schizophrenic patients using six neuropsychological tests that evaluate the dorsolateral prefrontal cortex functions, i.e., working memory, executive functions, and strategic performance. They then analyzed the test performances with a cluster analysis, which produced a four-cluster solution. The results support the hypothesis that neuropsychological dysfunctions in schizophrenia are heterogeneous. The performances on many of the neuropsychological tests were also strongly correlated with verbal and nonverbal IQ, as measured by the Wechsler Adult Intelligence Scale–Revised.
Key Words: Schizophrenia • Frontal Lobe Functions • Cognitive Heterogeneity
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