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Influence of the Apolipoprotein E Type 4 Allele on Cerebral Glucose Metabolism in Alzheimer's Disease Patients

Received April 4, 2001; revised November 7, 2001; accepted November 15, 2001. From the Department of Neuropsychiatry, Kangwon National University College of Medicine, Chunchon (K.U.L., J.H.L.); Departments of Nuclear Medicine (J.S.L., D.S.L., M.C.L.) and Neuropsychiatry (J.I.W.), Seoul National University College of Medicine, Seoul; and Neuroscience Research Institute of Medical Research Center and Clinical Research Institute of Seoul National University Hospital, Seoul, South Korea (K.W.K., J.H.J., D.Y.L., J.C.Y., J.I.W.). Address correspondence to Dr. Woo, Department of Neuropsychiatry, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, South Korea. E-mail: jiwoomd{at}plaza.snu.ac.kr

It is still unclear whether apolipoprotein E epsilon 4 (APOE E4) influences the cerebral glucose metabolism abnormalities found in Alzheimer's disease (AD), although APOE E4 is a well-known risk factor for AD. [¹⁸F]Fluorodeoxyglucose PET was conducted in patients with very mild (n=17), mild (n=27), and moderate-to-severe (n=19) AD. The presence of APOE E4 was associated with greater reduction of glucose metabolism in the left inferior temporal region in very mild AD but neither in mild nor in moderate-to-severe AD. These findings favor the hypothesis that APOE E4 is related mainly to the development of AD, not to its progression.

Key Words: Alzheimer's Disease • Apolipoprotein E • PET Studies

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