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Cognitive Deficits in Patients With Hepatic Cirrhosis and in Liver Transplant Recipients

Received February 28, 2001; revised July 30, 2001; accepted August 1, 2001. From the Psychobiology Laboratory, Department of Psychiatry, University of Oviedo, Oviedo, Spain. Address correspondence to Dr. Arias, Laboratorio de Psicobiologéa, Facultad de Psicologia, Universidad de Oviedo, Plaza Feijoo s/n, 33003 Oviedo, Spain.

This study assessed cognitive deficit in patients diagnosed with different stages of hepatic cirrhosis and in liver transplant recipients. A short protocol consisting of several psychometric tests was used. Cirrhotic patients showed a degree of mental impairment in all the functions studied. The severity of the deficit was related to the degree of hepatic dysfunction. In contrast, liver transplant recipients presented only a slightly altered cerebral dysfunction in comparison to the control group. Their cognitive capacity was slightly better than that of patients with asymptomatic cirrhosis.

Key Words: Hepatic Encephalopathy • Hepatic Cirrhosis • Hepatic Transplant

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