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Clinical Correlates of Aggressive Behavior After Traumatic Brain Injury

From the Department of Psychiatry at the University of Iowa College of Medicine, Iowa City, Iowa (A.T., R.E.J., R.G.R.;) and the Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan (A.T.). Address correspondence to Dr. Jorge, Department of Psychiatry, University of Iowa College of Medicine, MEB / Psychiatry Research, 500 Newton Road, Iowa City, Iowa 52242. E-mail: ricardo-jorge{at}uiowa.edu

The authors assessed aggressive behavior in 89 patients with traumatic brain injury (TBI) and 26 patients with multiple trauma but without TBI using a quantitative scale (the Overt Aggression Scale) and examined its clinical correlates. Aggressive behavior was found in 33.7% of TBI patients and 11.5% of patients without TBI during the first 6 months after injury. Aggressive behavior was significantly associated with the presence of major depression, frontal lobe lesions, poor premorbid social functioning, and a history of alcohol and substance abuse. Interventions aimed at treatment of depression and substance abuse and enhancing social support may help reduce the severity of this disruptive behavior.

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